解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The purpose of this work was to study the contractile activity of intracerebral microarterioles and their sensitivity to the calcium antagonist nimodipine. Potassium depolarization evoked contraction and rhythmic activity that was blocked by nimodipine (IC50 0.08 nM). High concentrations of noradrenaline and prostagla...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Bay U 3405 is a novel thromboxane receptor blocker. The present investigations describe its effects on experimental canine and porcine cardiac damage. In anesthetized dogs, a coronary artery was occluded for 6 hours and reperfused for 30 minutes. Bay U 3405 was administered intravenously 15 minutes after occlusion (1 ...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Many nonsteroidal anti-inflammatory drugs exert their effects by inhibiting the synthesis of prostanoids. More specifically, these agents block the synthesis of prostaglandin endoperoxide G2 from arachidonic acid by competing with arachidonate for binding to the cyclooxygenase active site of prostaglandin endoperoxide...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::Using in vivo brain microdialysis, we studied amino acid release in the striatum and cortex of eight rats following permanent middle cerebral artery occlusion. We then processed all brains for histopathologic assessment of the volume of ischemic damage 4 hours after occlusion. Ischemic damage was varied by occlusion o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.12.1727
更新日期:1990-12-01 00:00:00
abstract::U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion of alpha-tocopherol with the amine of the previously described 21-aminosteroids (e.g., U74006F). U78517F inhibited 200 microM FeCl2-initiated lipid peroxidation in rat brain homogenates by 50...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::Brain injury, including ischemia, changes normal astrocytes into reactive species that hypertrophy and begin to proliferate. Understanding the mechanisms that underlie these changes could lead to new abilities to promote regeneration and retard neural degeneration after ischemia. Because ionic changes occur after nonn...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::Stroke is a complex disease, with both genetic and environmental factors having a role in its pathogenesis. A review of past studies shows some evidence of genetic influences in the development of stroke. This is supported by studies of cardiovascular disease, which indicate major genetic influences at several levels ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:
更新日期:1990-11-01 00:00:00
abstract::A 39-year-old woman had an embolic upper division middle cerebral artery branch occlusion 3 hours after smoking the free base of cocaine ("crack"). Radionuclide ventriculography demonstrated cardiomyopathy, and echocardiography documented a left atrial thrombus. This case demonstrates that embolism is one mechanism of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.11.1632
更新日期:1990-11-01 00:00:00
abstract::We investigated the prevalence of carotid atherosclerosis, including mild early lesions, and its association with cervical bruits and various risk factors (age, male sex, hypertension, hyperlipidemia, diabetes mellitus, obesity, and cigarette smoking) in 232 consecutive Japanese patients. High-resolution real-time B-m...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.11.1567
更新日期:1990-11-01 00:00:00
abstract::We have studied a new high-affinity competitive N-methyl-D-aspartate antagonist, D-CPP-ene (SDZ-EAA 494), in two models of focal cerebral ischemia. In the cat middle cerebral artery occlusion model (6 hours' survival), pretreatment with D-CPP-ene reduced infarct size by 64% (15 mg/kg dose) and 60% (4.5 mg/kg dose). Th...
journal_title:Stroke
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::Platelet-activating factor is a potent mediator of inflammation, which has untoward effects on cerebrovascular and neural elements. While several investigators have reported attenuation of ischemic damage after treatment with antagonists of platelet-activating factor, no study has proved endogenous production of plate...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.10.1452
更新日期:1990-10-01 00:00:00
abstract::We investigated the effects of phenytoin on the rate of enzymatic release of free fatty acids and on the levels of energy metabolites and nucleoside phosphates in ischemic brain. Phenytoin (10 mg/kg i.v.) was administered 30 minutes before the onset of ischemia induced in 30 male Wistar rats by occluding the basilar a...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.9.1326
更新日期:1990-09-01 00:00:00
abstract::We investigated seasonal variation in the incidence of cerebral stroke among the general population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. During the 24-year follow-up period, 311 cases of cerebrovascular diseases occurred. The date or month of onset was determined in 308 cases,...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.9.1262
更新日期:1990-09-01 00:00:00
abstract::Recent data strongly suggest that repetitive ischemic episodes have an adverse cumulative effect on development of edema and tissue damage. We wanted to assess further whether special risks such as exacerbation of extracellular acidification reflecting progressive exhaustion of the capacity to buffer H+ in the extrace...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.8.1192
更新日期:1990-08-01 00:00:00
abstract::Recent clinical studies emphasize the importance of early (less than 12 hours after onset) treatment of patients with acute ischemic stroke. Therapies have been proposed as being effective because of early clinical improvement. The frequency and degree of spontaneous improvement in such patients, however, is unknown. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.7.1008
更新日期:1990-07-01 00:00:00
abstract::We report two patients with mixed transcortical aphasia following left frontal lobe infarctions. Although there was no evidence of anatomic isolation of the speech area on computed tomograms or magnetic resonance imaging scans, single-photon emission computed tomography in one case demonstrated diminished blood flow o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.6.953
更新日期:1990-06-01 00:00:00
abstract::An anecdotal series of nine patients (three men and six women with an average age of 57 years) presented with progressive neurologic deterioration while on medical therapy for large right hemispheric cerebral infarction. Clinical signs of uncal herniation (anisocoria or fixed and dilated pupils, and/or left hemiplegia...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.6.874
更新日期:1990-06-01 00:00:00
abstract::We measured cerebral blood flow and somatosensory evoked potentials during transient focal cerebral ischemia in cats to compare the effects of four commonly used anesthetic regimens: ketamine/fentanyl/N2O (fentanyl), pentobarbital, ketamine/alpha-chloralose (alpha-chloralose), and ketamine/halothane/N2O (halothane). S...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.5.795
更新日期:1990-05-01 00:00:00
abstract::The effect of cigarette smoking on extracranial carotid atherosclerosis was studies by obtaining cigarette smoking histories and information on other potential risk factors from consecutive patients undergoing carotid arteriography. At least on extracranial carotid artery was visualized in 752 patients in whom the ext...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.5.707
更新日期:1990-05-01 00:00:00
abstract::Experimental subarachnoid hemorrhage was induced in 52 adult male Wistar rats by microsurgical transclival basilar artery puncture. Telencephalic blood flow measured in 24 rats with subarachnoid hemorrhage was compared with that in 23 sham-operated rats and 10 unoperated control rats using the [14C]butanol indicator f...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.4.577
更新日期:1990-04-01 00:00:00
abstract::Both platelet activating factor and eicosanoids participate in the cerebrovascular response to ischemia. Eicosanoids also modulate cerebrovascular tone under normal physiologic circumstances, but a similar role for platelet activating factor has not been investigated. Therefore, using 16 rats, we studied the effects o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.3.459
更新日期:1990-03-01 00:00:00
abstract::We tested the hypothesis that hypertension is more common and cardiac embolism less common in patients with lacunar infarction than in patients with other types of cerebral infarction. We studied risk factor profiles in a series of 102 consecutive patients with a lacunar infarct and 202 consecutive patients with a car...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.3.375
更新日期:1990-03-01 00:00:00
abstract::As a preliminary investigation into the cerebral effects of mechanical cardiac assist devices, using transcranial Doppler ultrasonography I examined the basal cerebral arteries in three patients placed on an intra-aortic balloon pump. Unassisted systoles had normal blood velocities and waveforms. When the pump was in ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.3.484
更新日期:1990-03-01 00:00:00
abstract::The methionine analogue methionine sulfoximine was administered to 10 rats 24 hours before occlusion of the proximal left middle cerebral artery. Three days later the rats were decapitated and the brain infarct volumes were compared with those in 10 control rats that received saline before middle cerebral artery occlu...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.2.322
更新日期:1990-02-01 00:00:00
abstract::I used leg and arm paresis to predict outcome measured as extremity function in a prospective study of 75 consecutive hemiplegic patients admitted to an inpatient stroke rehabilitation unit. In each patient, extremity paresis was quantified according to the five-point scoring system advised by the Medical Research Cou...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.2.247
更新日期:1990-02-01 00:00:00
abstract::Many patients suffer a stroke early after a transient ischemic attack, but the reason why is often unclear. We studied 12 patients with less than 75% stenosis of the internal carotid artery and a single hemispheric transient ischemic attack lasting less than 1 hour who had a normal neurologic examination 3-13 hours la...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.1.40
更新日期:1990-01-01 00:00:00
abstract::The double subarachnoid hemorrhage canine model was used to test the prophylactic value of immunosuppression in the prevention of cerebral vasospasm after subarachnoid hemorrhage. Dogs treated with cyclosporine A following the regimen prescribed for organ transplant procedures in patients showed a significant reductio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.1.133
更新日期:1990-01-01 00:00:00
abstract::Using the dexamethasone suppression test, we studied the activity of the hypothalamic-pituitary-adrenal axis within the first week after onset in 62 patients with acute ischemic stroke. Compared with two control groups (one comprising 25 elderly patients with various acute medical disorders and the other comprising 33...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.12.1685
更新日期:1989-12-01 00:00:00
abstract::We determined the immediate effects of pentoxifylline on cerebral blood flow in 10 patients with cerebrovascular disease; four received 400 mg and six received 800 mg pentoxifylline orally. Regional cerebral blood flow was measured before (baseline) and 2, 4, and 6 hours after pentoxifylline administration using the x...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.12.1662
更新日期:1989-12-01 00:00:00
abstract::We looked at FiO2, choice of anesthetic, nutritional status, and body temperature in a gerbil model of forebrain ischemia to determine their effect on data interpretation, ischemic outcome, and extent of pharmacologic protection. We subjected 484 gerbils to 5 minutes of forebrain ischemia under different experimental ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.11.1545
更新日期:1989-11-01 00:00:00
abstract::Contrast-enhanced computed tomography of the neck permits low-risk evaluation of morphologic complications of carotid plaque, including (and foremost) calcification. To investigate the patterns and clinical significance of calcified deposits in the cervical carotid arteries using computed tomography we studied 40 pati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.11.1472
更新日期:1989-11-01 00:00:00
abstract::We produced unilateral photochemical infarcts in the hindlimb sensorimotor neocortex of 186 rats by intravenous injection of the fluorescein derivative rose bengal and focal illumination of the intact skull surface. Infarcted rats showed specific, long-lasting deficits in tactile and proprioceptive placing reactions o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.10.1383
更新日期:1989-10-01 00:00:00
abstract::MRI is becoming the imaging modality of choice in patients with ischemic cerebrovascular disease although CT is still the test of choice to exclude acute hemorrhagic stroke. We have briefly reviewed characteristic features of ischemic and hemorrhagic cerebrovascular disease as well as vascular anomalies as seen on MRI...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.20.9.1279
更新日期:1989-09-01 00:00:00
abstract::We compared three self-rating scales (the Geriatric Depression Scale, the Zung Scale, and the Center for Epidemiologic Studies Depression Scale) with three examiner-rating scales (the Hamilton Rating Scale, the Comprehensive Psychopathological Rating Scale-Depression, and the Cornell Scale), to see which was best for ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.9.1190
更新日期:1989-09-01 00:00:00
abstract::We studied 1,273 patients with ischemic cerebral infarction who were entered into the Stroke Data Bank, a prospective, observational study involving four university hospitals and the Biometry and Field Studies Branch of the National Institute of Neurological Disorders and Stroke. Forty patients had noniatrogenic recur...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.983
更新日期:1989-08-01 00:00:00
abstract::Clinical and pathologic observations have suggested analogies between the developing nervous system of ferrets (Mustela putorius furo) and those of more traditional animal models employed in stroke research. Experimental work has demonstrated advantages of the ferret as a model of visual development. We performed in v...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.1085
更新日期:1989-08-01 00:00:00
abstract::Ischemia due to middle cerebral artery occlusion was studied in 29 rats from 1 to 24 hours after occlusion using magnetic resonance imaging. Images were made before and after the injection of a superparamagnetic iron oxide compound, AMI-25. Subtraction images demonstrated the region of perfusion deficit as early as 1 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.8.1032
更新日期:1989-08-01 00:00:00
abstract::We examined cerebral lipid peroxidation, estimated by a thiobarbituric acid test, in rat brain regions after 30 minutes of severe forebrain ischemia and at recirculation periods of up to 72 hours. The lipid peroxide levels remained unaltered in all brain regions during ischemia and during the first hour of recirculati...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.7.918
更新日期:1989-07-01 00:00:00
abstract::During perinatal asphyxia, cerebral blood flow is markedly reduced in the gray and white matter of the telencephalon. Since previous work has implicated prostaglandins in the control of blood flow, we tested the hypothesis that a thromboxane synthesis inhibitor would improve cerebral blood flow and blunt the metabolic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.6.809
更新日期:1989-06-01 00:00:00
abstract::In a consecutive series of 473 patients admitted within 72 hours after a subarachnoid hemorrhage, 91 (19%) had hydrocephalus on the initial computed tomogram. Consciousness was unimpaired in 25 of the 91 (28%). In 11 more patients acute hydrocephalus developed within 1 week after subarachnoid hemorrhage. Thirty-eight ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.20.6.747
更新日期:1989-06-01 00:00:00